From 23fad5a35423029e74b0d02c0558fcd02e1a2fc8 Mon Sep 17 00:00:00 2001 From: Loreen Alderson Date: Tue, 5 Aug 2025 09:27:12 +0000 Subject: [PATCH] Add 'In the Second Part of the Study' --- In-the-Second-Part-of-the-Study.md | 1 + 1 file changed, 1 insertion(+) create mode 100644 In-the-Second-Part-of-the-Study.md diff --git a/In-the-Second-Part-of-the-Study.md b/In-the-Second-Part-of-the-Study.md new file mode 100644 index 0000000..3916b1a --- /dev/null +++ b/In-the-Second-Part-of-the-Study.md @@ -0,0 +1 @@ +
OBJECTIVE: UCP2 and UCP3 are newly discovered uncoupling proteins, which are thought to underlie the variability in energy metabolism in humans. Mutations in the UCP2 and/or UCP3 gene have been associated with sleeping metabolic rate. Recently we reported that skeletal muscle UCP3 mRNA expression was positively correlated with sleeping metabolic rate in Pima Indians. To study whether genetic variation in the promoter region of UCP3 contributed to the variation in expression of UCP3, we screened part of the proximal promoter region for polymorphisms. METHODS: In the first part of the study, the proximal promoter region of UCP3 was screened by direct sequencing in 24 non-diabetic Pima Indians (range body mass index (BMI): 18-47 kg/m2) (Schrauwen et al. Diabetes 1999 \ No newline at end of file